Heksaprenil difosfat sintaza (geranilgeranil-difosfat specifična)
Prijeđi na navigaciju
Prijeđi na pretragu
| Heksaprenil difosfat sintaza (geranilgeranil-difosfat specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.82 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Heksaprenil difosfat sintaza (geranilgeranil-difosfat specifična) (EC 2.5.1.82, HexPS, (sve-E) heksaprenil difosfatna sintaza, (sve-trans) heksaprenil difosfatna sintaza, heksaprenil pirofosfatna sintaza, HexPPs, heksaprenil difosfatna sintaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:izopentenil-difosfat transferaza (dodaje 2 izopentenilne jedinice).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranilgeranil difosfat + 2 izopentenil difosfat 2 difosfat + sve-trans-heksaprenil difosfat
Ovaj enzim preferentno deluje na geranilgeranil difosfat.
Reference[uredi | uredi kod]
- ↑ Hemmi, H., Ikejiri, S., Yamashita, S. and Nishino, T. (2002). „Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus”. J. Bacteriol. 184: 615-620. PMID 11790729.
- ↑ Hemmi, H., Noike, M., Nakayama, T. and Nishino, T. (2002). „Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations”. Biochem. Biophys. Res. Commun. 297: 1096-1101. PMID 12372398.
- ↑ Sun, H.Y., Ko, T.P., Kuo, C.J., Guo, R.T., Chou, C.C., Liang, P.H. and Wang, A.H. (2005). „Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures”. J. Bacteriol. 187: 8137-8148. PMID 16291686.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.