Glutaminil-peptid ciklotransferaza
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| Glutaminil-peptid ciklotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.2.5 | ||||||||
| CAS broj | 37257-21-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutaminil-peptid ciklotransferaza (EC 2.3.2.5, glutaminil-tRNK ciklotransferaza, glutaminil ciklaza, glutaminil-transfer ribonukleatna ciklotransferaza) je enzim sa sistematskim imenom L-glutaminil-peptid gama-glutamiltransferaza (ciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-glutaminil-peptid 5-oksoprolil-peptid + NH3
Ovaj enzim učestvuje u formiranju tirotropin oslobađajućeg hormona i drugih biološki aktivnih peptida koji sadrže N-terminalne piroglutamilne ostatke.
Reference[uredi | uredi kod]
- ↑ Busby, W.H., Quackenbush, G.E., Humm, J., Youngblood, W.W. and Kizer, J.S. (1987). „An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes”. J. Biol. Chem. 262: 8532-8536. PMID 3597387.
- ↑ Fischer, W.H. and Spiess, J. (1987). „Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides”. Proc. Natl. Acad. Sci. USA 84: 3628-3632. PMID 3473473.
- ↑ Messer, M. and Ottesen, M. (1965). „Isolation and properties of glutamine cyclotransferase of dried papaya latex”. C.R. Trav. Lab. Carlsberg 35: 1-24. PMID 5846578.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.