Glutamil-tRNK reduktaza
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| Glutamil-tRNK reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.70 | ||||||||
| CAS broj | 119940-26-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glutamil-tRNK reduktaza (EC 1.2.1.70, reduktaza glutamil-tRNK) je enzim sa sistematskim imenom L-glutamat-semialdehid:NADP+ oksidoreduktaza (formira L-glutamil-tRNKGlu).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-glutamat 1-semialdehid + NADP+ + tRNAGlu L-glutamil-tRNAGlu + NADPH + H+
Ovaj enzim formira deo puta za biosintezu 5-aminolevulinata iz glutamata, koji je poznat kao C5 put. Njega koriti većina eubakterija, i sve arhebakterije, alge i biljke.
Reference[uredi | uredi kod]
- ↑ von Wettstein, D., Gough, S. and Kannangara, C.G. (1995). „Chlorophyll biosynthesis”. Plant Cell 7: 1039-1057. PMID 12242396.
- ↑ Pontoppidan, B. and Kannangara, C.G. (1994). „Purification and partial characterisation of barley glutamyl-tRNAGlu reductase, the enzyme that directs glutamate to chlorophyll biosynthesis”. Eur. J. Biochem. 225: 529-537. PMID 7957167.
- ↑ Schauer, S., Chaturvedi, S., Randau, L., Moser, J., Kitabatake, M., Lorenz, S., Verkamp, E., Schubert, W.D., Nakayashiki, T., Murai, M., Wall, K., Thomann, H.-U., Heinz, D.W., Inokuchi, H, Söll, D. and Jahn, D. (2002). „Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate”. J. Biol. Chem. 277: 48657-48663. PMID 12370189.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.