Glukozamin-1-fosfat N-acetiltransferaza
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| Glukozamin-1-fosfat N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.157 | ||||||||
| CAS broj | 9031-91-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glukozamin-1-fosfat N-acetiltransferaza (EC 2.3.1.157) je enzim sa sistematskim imenom acetil-KoA:alfa-D-glukozamin-1-fosfat N-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + alfa-D-glukozamin 1-fosfat KoA + N-acetil-alfa-D-glukozamin 1-fosfat
Enzim iz nekoliko bakterija (e.g., Escherichia coli, Bacillus subtilis i Hemophilus influenzae) je bifunkcionalan i takođe deluje kao enzim EC 2.7.7.23, UDP-N-acetilglukozaminska difosforilaza.
Reference[uredi | uredi kod]
- ↑ Mengin-Lecreulx, D. and van Heijenoort, J. (1994). „Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis”. J. Bacteriol. 176: 5788-5795. PMID 8083170.
- ↑ Gehring, A.M., Lees, W.J., Mindiola, D.J., Walsh, C.T. and Brown, E.D. (1996). „Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli”. Biochemistry 35: 579-585. PMID 8555230.
- ↑ Olsen, L.R. and Roderick, S.L. (2001). „Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites”. Biochemistry 40: 1913-1921. PMID 11329257.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.