Glikogenin glukoziltransferaza

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Glikogenin glukoziltransferaza
Rabbit muscle glycogenin structure.jpg
Identifikatori
EC broj 2.4.1.186
CAS broj 117590-73-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glikogenin glukoziltransferaza (EC 2.4.1.186, glikogenin, prajmirajuća glukoziltransferaza, UDP-glukoza:glikogenin glukoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-glukoza:glikogenin alfa-D-glukoziltransferaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-glukoza + glikogenin \rightleftharpoons UDP + alfa-D-glukozilglikogenin

Ovaj enzim prvo katalizuje sopstvenu glukozilaciju, normalno na Tyr-194 proteina ako je grupa slobodna. On zatim vrši glukozilaciju glukozilnih grupa dok se formira molekul sa 5--13 ostataka. Dalje produžavanje glikogenskog lanca izvodi enzim EC 2.4.1.11, glikogen (skrob) sintaza.

Reference[uredi - уреди]

  1. Krisman, C.R. and Barengo, R. (1975). "A precursor of glycogen biosynthesis: α-1,4-glucan-protein". Eur. J. Biochem. 52: 117-123. PMID 809265. 
  2. Pitcher, J., Smythe, C., Campbell, D.G. and Cohen, P. (1987). "Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin". Eur. J. Biochem. 169: 497-502. PMID 3121316. 
  3. Pitcher, J., Smythe, C. and Cohen, P. (1988). "Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle". Eur. J. Biochem. 176: 391-395. PMID 2970965. 
  4. Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). "The biogenesis of rabbit-muscle glycogen". u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84. 
  5. Rodriguez, I.R. and Whelan, W.J. (1985). "A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine". Biochem. Biophys. Res. Commun. 132: 829-836. PMID 4062948. 
  6. Lomako, J., Lomako, W.M. and Whelan, W.J. (1988). "A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis". FASEB J. 2: 3097-3103. PMID 2973423. 
  7. Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). "Catalytic activities of glycogenin additional to autocatalytic self-glucosylation". J. Biol. Chem. 270: 15315-15319. PMID 7797519. 
  8. Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). "A new look at the biogenesis of glycogen". FASEB J. 9: 1126-1137. PMID 7672505. 
  9. Mu, J. and Roach, P.J. (1998). "Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism". J. Biol. Chem. 273: 34850-34856. PMID 9857012. 
  10. Gibbons, B.J., Roach, P.J. and Hurley, T.D. (2002). "Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin". J. Mol. Biol. 319: 463-177. PMID 12051921. 

Literatura[uredi - уреди]

  • Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). "The biogenesis of rabbit-muscle glycogen". u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84. 

Spoljašnje veze[uredi - уреди]