Gentamicin 3'-N-acetiltransferaza
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| Gentamicin 3'-N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.60 | ||||||||
| CAS broj | 58500-58-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gentamicin 3'-N-acetiltransferaza (EC 2.3.1.60, gentamicinska acetiltransferaza I, aminoglikozidna acetiltransferaza AAC(3)-1, gentamicinska 3'-N-acetiltransferaza, acetil-KoA:gentamicin-C N3'-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:gentamicin-C N3'-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + gentamicin C KoA + N3'-acetilgentamicin C
Ovaj enzim takođe acetiluje sisomicin.
Reference[uredi | uredi kod]
- ↑ Angelatou, F., Litsas, S.B. and Kontomichalou, P. (1982). „Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa”. J. Antibiot. 35: 235-244. PMID 6281224.
- ↑ Biddlecome, S., Haas, J., Davies, G.H., Miller, D., Rane, F. and Daniels, P.J.L. (1976). „Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate”. Antimicrob. Agents Chemother. 9: 951-955. PMID 820250.
- ↑ Williams, J.W. and Northrop, D.B. (1976). „Purification and properties of gentamicin acetyltransferase I”. Biochemistry 15: 125-131. PMID 764855.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.