Gama-Renin
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| Gama-Renin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.54 | ||||||||
| CAS broj | 85270-20-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Gama-Renin (EC 3.4.21.54, Gamma-renin) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Leu-Leu veze u sintetičkom tetradekapeptidu reninskog supstrata (konj), čime se formira angiotensin I, ali ne i aktivni prirodni angiotenzinogen, za razliku od renina (EC 3.4.23.15). Takođe dolazi do hidrolize Bz-Arg-p-nitroanilida
Ovaj enzim je član tkivne kalikreinske familije.
Reference[uredi | uredi kod]
- ↑ Poe, M., Wu, J.K., Florance, J.R., Rodkey, J.A., Bennett, C.D. and Hoogsteen, K. (1983). „Purification and properties of renin and γ-renin from the mouse submaxillary gland”. J. Biol. Chem. 258: 2209-2216. PMID 6337154.
- ↑ Drinkwater, C.C., Evans, B.A. and Richards, R.I. (1988). „Sequence and expression of mouse γ-renin”. J. Biol. Chem. 263: 8565-8568. PMID 3288617.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.