Fragilizin

Izvor: Wikipedia
Fragilizin
Identifikatori
EC broj 3.4.24.74
CAS broj 188596-63-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Fragilizin (EC 3.4.24.74, Bacteroides fragilis (entero)toksin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Širokoa proteolitička specifičnost, između ostalog dolazi do hidrolize veza -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly

Smatra se da je ovaj enzim uzročnik dijareje kod životinja i ljudi.

Reference[uredi - уреди]

  1. Moncrief, J.S., Obiso, R., Jr., Barroso, L.A., Kling, J.J., Wright, R.L., Van Tassell, R.L., Lyerly, D.M. and Wilkins, T.D. (1995). "The enterotoxin of Bacteroides fragilis is a metalloprotease". Infect. Immun. 63: 175–181. PMID 7806355. 
  2. Obiso, R.J., Jr., Lyerly, D.M., Van Tassell, R.L. and Wilkins, T.D. (1995). "Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo". Infect. Immun. 63: 3820–3826. PMID 7558286. 
  3. Donelli, G., Fabbri, A. and Fiorentini, C. (1996). "Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells". Infect. Immun. 64: 113–119. PMID 8557328. 
  4. Koshy, S.S., Montrose, M.H. and Sears, C.L. (1996). "Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis". Infect. Immun. 64: 5022–5028. PMID 8945541. 
  5. Kling, J.J., Wright, R.L., Moncrief, J.S. and Wilkins, T.D. (1997). "Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis". FEMS Microbiol. Lett. 146: 279–284. PMID 9011050. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]