Fosfatidil-N-metiltanolamin N-metiltransferaza
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| Fosfatidil-N-metiltanolamin N-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.71 | ||||||||
| CAS broj | 67167-73-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosfatidil-N-metiltanolamin N-metiltransferaza (EC 2.1.1.71, fosfatidilmonometiltanolaminska metiltransferaza, metiltransferaza II, fosfolipidna metiltransferaza, PLMT, fosfatidil-N-metiltanolaminska metiltransferaza, fosfatidil-N-monometiltanolaminska metiltransferaza, fosfatidiletanolaminska metiltransferaza I, fosfatidilmonometiltanolaminska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:fosfatidil-N-metiltanolamin N-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + fosfatidil-N-metiletanolamin S-adenozil-L-homocistein + fosfatidil-N-dimetiletanolamin
Enzim takođe katalizuje transfer dodatne metil grupe, čime se formira [[fosfatidilholin].
Reference[uredi | uredi kod]
- ↑ Hirata, F., Viveros, O.H., Diliberto, E.J., Jr. and Axelrod, J. (1978). „Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine”. Proc. Natl. Acad. Sci. USA 75: 1718-1721. PMID 25437.
- ↑ Schneider, W.J. and Vance, D.E. (1979). „Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities”. J. Biol. Chem. 254: 3886-3891. PMID 438165.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.