Floroizovalerofenon sintaza
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| Floroizovalerofenon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.156 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Floroizovalerofenon sintaza (EC 2.3.1.156, valerofenonska sintaza, 3-metil-1-(trihidroksifenil)butan-1-on sintaza) je enzim sa sistematskim imenom izovaleril-KoA:malonil-KoA aciltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- izovaleril-KoA + 3 malonil-KoA 4 KoA + 3 CO2 + 3-metil-1-(2,4,6-trihidroksifenil)butan-1-on
Ovaj enzim je blisko srodan sa EC 2.3.1.74, naringenin-halkon sintazom. Produkt, 3-metil-1-(2,4,6-trihidroksifenil)butan-1-on, je floroizovalerofenon.
Reference[uredi | uredi kod]
- ↑ Fung, S.Y., Zuurbier, K.W.M., Paniego, N.B., Scheffer, J.J.C. and Verpoorte, R. (1997). „Enzymes from the biosynthesis of hop α and β acids”. Proc. 26th Congr. Eur. Brew. Conv.: 215-221.
- ↑ Zuurbier, K.W.M., Leser, J., Berger, T., Hofte, A.J.P., Schroder, G., Verpoorte, R. and Schroder, J. (1998). „4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates”. Phytochemistry 49: 1945-1951.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.