Fitanoil-KoA dioksigenaza
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| Fitanoil-KoA dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.18 | ||||||||
| CAS broj | 185402-46-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fitanoil-KoA dioksigenaza (EC 1.14.11.18, fitanoil-KoA hidroksilaza) je enzim sa sistematskim imenom fitanoil-KoA, 2-oksoglutarat:kiseonik oksidoreduktaza (2-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- fitanoil-KoA + 2-oksoglutarat + O2 2-hidroksifitanoil-KoA + sukcinat + CO2
Ovaj enzim je deo metaboličkog puta alfa oksidacije peroksisomalne fitanske kiseline. Za rad ovog enzima su neophodni Fe2+ i askorbat.
Reference[uredi | uredi kod]
- ↑ Jansen, G.A., Mihalik, S.J., Watkins, P.A., Jakobs, C., Moser, H.W. and Wanders, R.J.A. (1998). „Characterization of phytanoyl-CoA hydroxylase in human liver and activity measurements in patients with peroxisomal disorders”. Clin. Chim. Acta 271: 203-211. PMID 9565335.
- ↑ Jansen, G.A., Mihalik, S.J., Watkins, P.A., Moser, H.W., Jakobs, C., Denis, S. and Wanders, R.J.A. (1996). „Phytanoyl-CoA hydroxylase is present in human liver, located in peroxisomes, and deficient in Zellweger syndrome: direct, unequivocal evidence for the new, revised pathway of phytanic acid α-oxidation in humans”. Biochem. Biophys. Res. Commun. 229: 205-210. PMID 8954107.
- ↑ Jansen, G.A., Ofman, R., Ferdinandusse, S., Ijlst, L., Muijsers, A.O., Skjeldal, O.H., Stokke, O., Jakobs, C., Besley, G.T.N., Wraith, J.E. and Wanders, R.J.A. (1997). „Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene”. Nat. Genet. 17: 190-193. PMID 9326940.
- ↑ Mihalik, S.J., Rainville, A.M. and Watkins, P.A. (1995). „Phytanic acid α-oxidation in rat liver peroxisomes. Production of α-hydroxyphytanoyl-CoA and formate is enhanced by dioxygenase cofactors”. Eur. J. Biochem. 232: 545-551. PMID 7556205.
- ↑ Mihalik, S.J., Morrell, J.C., Kim, D., Sacksteder, K.A., Watkins, P.A. and Gould, S.J. (1997). „Identification of PAHX, a Refsum disease gene”. Nat. Genet. 17: 185-189. PMID 9326939.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.