Fenilalaninska amonijak-lijaza

Izvor: Wikipedia
Fenilalaninska amonijak-lijaza
Phenylalanine ammonia lysase active site.png
Identifikatori
EC broj 4.3.1.24
CAS broj 9024-28-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Fenilalaninska amonijak-lijaza (EC 4.3.1.24, fenilalaninska deaminaza, fenilalaninska amonijum-lijaza, PAL, L-fenilalaninska amonijak-lijaza, Phe amonijak-lijaza) je enzim sa sistematskim imenom L-fenilalanin amonijak-lijaza (formira trans-cinamat).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-fenilalanin \rightleftharpoons trans-cinamat + NH3

Ovaj enzim je član familije lijaza aromatičnih aminokiselina.

Reference[uredi - уреди]

  1. Koukol, J. and Conn, E.E. (1961). "The metabolism of aromatic compounds in higher plants. IV. Purification and properties of the phenylalanine deaminase of Hordeum vulgare". J. Biol. Chem. 236: 2692–2698. PMID 14458851. 
  2. Young, M.R. and Neish, A.C. (1966). "Properties of the ammonia-lyases deaminating phenylalanine and related compounds in Triticum sestivum and Pteridium aquilinum". Phytochemistry 5: 1121–1132. 
  3. Louie, G.V., Bowman, M.E., Moffitt, M.C., Baiga, T.J., Moore, B.S. and Noel, J.P. (2006). "Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases". Chem. Biol. 13: 1327–1338. PMID 17185228. 
  4. Calabrese, J.C., Jordan, D.B., Boodhoo, A., Sariaslani, S. and Vannelli, T. (2004). "Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis". Biochemistry 43: 11403–11416. PMID 15350127. 
  5. Ritter, H. and Schulz, G.E. (2004). "Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase". Plant Cell 16: 3426–3436. PMID 15548745. 
  6. Watts, K.T., Mijts, B.N., Lee, P.C., Manning, A.J. and Schmidt-Dannert, C. (2006). "Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family". Chem. Biol. 13: 1317–1326. PMID 17185227. 
  7. Appert, C., Logemann, E., Hahlbrock, K., Schmid, J. and Amrhein, N. (1994). "Structural and catalytic properties of the four phenylalanine ammonia-lyase isoenzymes from parsley (Petroselinum crispum Nym.)". Eur. J. Biochem. 225: 491–499. PMID 7925471. 
  8. Cochrane, F.C., Davin, L.B. and Lewis, N.G. (2004). "The Arabidopsis phenylalanine ammonia lyase gene family: kinetic characterization of the four PAL isoforms". Phytochemistry 65: 1557–1564. PMID 15276452. 
  9. Schwede, T.F., Rétey, J. and Schulz, G.E. (1999). "Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile". Biochemistry 38: 5355–5361. PMID 10220322. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]