Enzim aktiviranja format-C-acetiltransferaze
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| Enzim aktiviranja format-C-acetiltransferaze | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.97.1.4 | ||||||||
| CAS broj | 206367-15-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Enzim aktiviranja format-C-acetiltransferaze (EC 1.97.1.4, PFL aktivaza, PFL-glicin:S-adenozil-L-metionin H transferaza (flavodoksin-oksidacija, S-adenozil-L-metionin-razlaganje), aktivirajući enzim format acetiltransferaze, format acetiltransferaza-glicin dihidroflavodoksin:S-adenozil-L-metionin oksidoreduktaza (S-adenozil-L-metionin razlaganje)) je enzim sa sistematskim imenom (format C-acetiltransferaza)-glicin dihidroflavodoksin:S-adenozil-L-metionin oksidoreduktaza (S-adenozil-L-metionin razlaganje).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + dihidroflavodoksin + [format C-acetiltransferaza]-glicin 5'-dezoksiadenozin + L-metionin + flavodoksin semihinon + [format C-acetiltransferaza]-glicin-2-il radical
Ovaj enzim je gvožđe-sumporni protein.
Reference[uredi | uredi kod]
- ↑ Frey, M., Rothe, M., Wagner, A.F.V. and Knappe, J. (1994). „Adenosylmethionine-dependent synthesis of the glycyl radical in pyruvate formate-lyase by abstraction of the glycine C-2 pro-S hydrogen atom”. J. Biol. Chem. 269: 12432-12437. PMID 8175649.
- ↑ Wagner, A.F.V., Frey, M., Neugebauer, F.A., Schäfer, W. and Knappe, J. (1992). „The free radical in pyruvate formate-lyase is located on glycine-734”. Proc. Natl. Acad. Sci. USA 89: 996-1000. PMID 1310545.
- ↑ Frey, P.A. (2001). „Radical mechanisms in enzymatic catalysis”. Annu. Rev. Biochem. 70: 121-148. PMID 11395404.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.