Ent-kopalil difosfatna sintaza
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| Ent-kopalil difosfatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.5.1.13 | ||||||||
| CAS broj | 9055-64-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ent-kopalil difosfatna sintaza (EC 5.5.1.13, ent-kaurenska sintaza A, ent-kaurenska sintetaza A, ent-CDP sintaza) je enzim sa sistematskim imenom ent-kopalil-difosfat lijaza (deciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranilgeranil difosfat ent-kopalil difosfat
Ovaj enzim je deo bifunkcionalnog enzima koji učestvuje u biosintezi kaurena.
Reference[uredi | uredi kod]
- ↑ Fall, R.R., West, C.A. (1971). „Purification and properties of kaurene synthetase from Fusarium moniliforme”. J. Biol. Chem. 246: 6913-6928. PMID 4331199.
- ↑ Sun, T.P. and Kamiya, Y. (1994). „The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis”. Plant Cell 6: 1509-1518. PMID 7994182.
- ↑ Kawaide, H., Imai, R., Sassa, T. and Kamiya, Y. (1997). „Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis”. J. Biol. Chem. 272: 21706-21712. PMID 9268298.
- ↑ Toyomasu, T., Kawaide, H., Ishizaki, A., Shinoda, S., Otsuka, M., Mitsuhashi, W. and Sassa, T. (2000). „Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase”. Biosci. Biotechnol. Biochem. 64: 660-664. PMID 10803977.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.