Dipeptidilna peptidaza II
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| Dipeptidilna peptidaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.14.2 | ||||||||
| CAS broj | 76199-23-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dipeptidilna peptidaza II (EC 3.4.14.2, dipeptidilna aminopeptidaza II, dipeptidilna arilamidaza II, karboksitripeptidaza, dipeptidilna arilamidaza II, DAP II, dipeptidil(amino)peptidaza II, dipeptidilarilamidaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalnog dipeptida, Xaa-Yaa!, preferentno kad je Yaa: Ala ili Pro. Supstrati su oligopeptidi, preferentno tripeptidi
Ova lizozomalna serinska peptidaza pripada familiji S28 (Pro-X karboksipeptidaznoj familiji). Maksimalno je aktivna pri kiselom pH.
Reference[uredi | uredi kod]
- ↑ McDonald, J.K., Reilly, T.J., Zeitman, B.B. and Ellis, S. (1968). „Dipeptidyl arylamidase II of the pituitary. Properties of lysyl-alanyl-β-naphthylamide hydrolysis: inhibition by cations, distribution in tissues and subcellular localization”. J. Biol. Chem. 243: 4143-4150. PMID 4969969.
- ↑ McDonald, J.K. and Schwabe, C. (1977). „Intracellular exopeptidases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- McDonald, J.K. and Schwabe, C. (1977). „Intracellular exopeptidases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391.