Delta11-masna-kiselina desaturaza
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| Delta11-masna-kiselina desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.19.5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Delta11-masna-kiselina desaturaza (EC 1.14.19.5, Delta11 desaturaza, masno kiselinska Delta11-desaturaza, TpDESN, Cro-PG, Delta11 masno kiselinska desaturaza, Z/E11-desaturaza, Delta11-palmitoil-KoA desaturaza) je enzim sa sistematskim imenom acil-KoA,vodonik donor:kiseonik Delta11-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + redukovani akceptor + O2 Delta11-acil-KoA + akceptor + 2H2O
Ovaj enzim je vezan za membranu. On ima citohromu b5-sličan domen u N-terminusu i sadrži tri histidinske koji se kritične za desaturaznu aktivnost.
Reference[uredi | uredi kod]
- ↑ Tonon, T., Harvey, D., Qing, R., Li, Y., Larson, T.R. and Graham, I.A. (2004). „Identification of a fatty acid Δ11-desaturase from the microalga Thalassiosira pseudonana”. FEBS Lett. 563: 28-34. PMID 15063718.
- ↑ Hao, G., O'Connor, M., Liu, W. and Roelofs, W.L. (2002). „Characterization of Z/E11- and Z9-desaturases from the obliquebanded leafroller moth, Choristoneura rosaceana”. J. Insect Sci. 2:26: 1-7.
- ↑ Rodriguez, F., Hallahan, D.L., Pickett, J.A. and Camps, F. (1992). „Characterization of the Δ11-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera:Noctuidae)”. Insect Biochem. Mol. Biol. 22: 143-148.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.