D-aspartatna ligaza
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| D-aspartatna ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.1.12 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
D-aspartatna ligaza (EC 6.3.1.12, Aslfm, UDP-MurNAc-pentapeptid:D-aspartat ligaza, D-aspartinska kiselina-aktivirajući enzim) je enzim sa sistematskim imenom D-aspartat:(beta-GlcNAc-(1->4)-Mur2Ac(oil-L-Ala-gama-D-Glu-L-Lis-D-Ala-D-Ala))n ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + D-aspartat + [beta-GlcNAc-(1->4)-Mur2Ac(oil-L-Ala-gama-D-Glu-L-Lys-D-Ala-D-Ala)]n [beta-GlcNAc-(1->4)-Mur2Ac(oil-L-Ala-gama-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + fosfat
Ovaj enzim formira deo puta peptidoglikanskog formiranja kod Gram-pozitivnih bakterija.
Reference[uredi | uredi kod]
- ↑ Staudenbauer, W. and Strominger, J.L. (1972). „Activation of D-aspartic acid for incorporation into peptidoglycan”. J. Biol. Chem. 247: 5095-5102. PMID 4262567.
- ↑ Staudenbauer, W., Willoughby, E. and Strominger, J.L. (1972). „Further studies of the D-aspartic acid-activating enzyme of Streptococcus faecalis and its attachment to the membrane”. J. Biol. Chem. 247: 5289-5296. PMID 4626717.
- ↑ Galperin, M.Y. and Koonin, E.V. (1997). „A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity”. Protein Sci. 6: 2639-2643. PMID 9416615.
- ↑ Bellais, S., Arthur, M., Dubost, L., Hugonnet, J.E., Gutmann, L., van Heijenoort, J., Legrand, R., Brouard, J.P., Rice, L. and Mainardi, J.L. (2006). „Aslfm, the D-aspartate ligase responsible for the addition of D-aspartic acid onto the peptidoglycan precursor of Enterococcus faecium”. J. Biol. Chem. 281: 11586-11594. PMID 16510449.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.