Citrat (Si)-sintaza

Izvor: Wikipedia
Citrat (Si)-sintaza
Identifikatori
EC broj 2.3.3.1
CAS broj 9027-96-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Citrat (Si)-sintaza (EC 2.3.3.1, (R)-limunska sintaza, citrat kondenzujući enzim, citrat oksaloacetatna lijaza ((pro-3S)-CH2COO-->acetil-KoA), citrat oksaloacetatna lijaza, KoA-acetilacija, citratna sintaza, citratna sintetaza, citrik sintaza, citratni kondenzujući enzim, citrogenaza, kondenzujući enzim, oksaloacetatna transacetaza, oksalacetinska transacetaza) je enzim sa sistematskim imenom acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formirane (pro-S)-karboksimetila).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + H2O + oksaloacetat \rightleftharpoons citrat + KoA

Stereospecifičnost ovog enzima je suprotna enzimu EC 2.3.3.3, citrat (Re)-sintazi, koji je nađen kod nekoliko anaerobih vrsta.

Reference[uredi - уреди]

  1. Gottschalk, G. (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7: 301–306. PMID 4974734. 
  2. Ochoa, S., Stern, J.R. and Schneider, M.C. (1951). "Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme". J. Biol. Chem. 193: 691–702. PMID 14907759. 
  3. Stern, J.R. (1961). "Oxalacetate transacetase (condensing enzyme, citrogenase)". u: Boyer, P,D., Lardy, H and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 367-380. 
  4. Rault-Leonardon, M., Atkinson, M.A., Slaughter, C.A., Moomaw, C.R. and Srere, P.A. (1995). "Azotobacter vinelandii citrate synthase". Biochemistry 34: 257–263. PMID 7819205. 
  5. Muir, J.M., Russell, R.J., Hough, D.W. and Danson, M.J. (1995). "Citrate synthase from the hyperthermophilic Archaeon, Pyrococcus furiosus". Prot. Eng. 8: 583–592. PMID 8532683. 
  6. Russell, R.J., Ferguson, J.M., Hough, D.W., Danson, M.J. and Taylor, G.L. (1997). "The crystal structure of citrate synthase from the hyperthermophilic archaeon Pyrococcus furiosus at 1.9 Å resolution". Biochemistry 36: 9983–9994. PMID 9254593. 

Literatura[uredi - уреди]

  • Stern, J.R. (1961). "Oxalacetate transacetase (condensing enzyme, citrogenase)". u: Boyer, P,D., Lardy, H and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 367-380. 

Spoljašnje veze[uredi - уреди]