Citohrom P450, familija 1, član A1

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Citohrom P450, familija 1, član A1‎‎
Identifikatori
Simboli CYP1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Vanjski ID OMIM108330 MGI88588 HomoloGene68062 GeneCards: CYP1A1 Gene
EC broj 1.14.14.1
Pregled RNK izražavanja
PBB GE CYP1A1 205749 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1543 13076
Ensembl ENSG00000140465 ENSMUSG00000032315
UniProt P04798 P00184
RefSeq (mRNA) NM_000499.3 NM_001136059.2
RefSeq (protein) NP_000490.1 NP_001129531.1
Lokacija (UCSC) Chr 15:
75.01 - 75.02 Mb
Chr 9:
57.55 - 57.55 Mb
PubMed pretraga [1] [2]

Citohrom P450, familija 1, član A1 je protein[1] koji je kod ljudi kodiran CYP1A1 genom.[2] Ovaj protein je član citohrom P450 superfamilije enzima.[3]

Funkcija[uredi - уреди]

CYP1A1 učestvuje u fazi I ksenobiotičkog metabolizma. Jedan od njegovih supstrata je teofilin. Inhibitori ovog enzima su fluorohinoloni i makrolidi. On se može indukovati aromatičnim ugljovodonicima.[4]

Reference[uredi - уреди]

  1. Kawajiri K (1999). "CYP1A1". IARC Scientific Publications (148): 159–72. PMID 10493257. 
  2. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. 
  3. Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157. 
  4. Beresford AP (1993). "CYP1A1: friend or foe?". Drug Metabolism Reviews 25 (4): 503–17. doi:10.3109/03602539308993984. PMID 8313840. 

Literatura[uredi - уреди]

  • Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. 
  • Masson LF, Sharp L, Cotton SC, Little J (2005). "Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.". American Journal of Epidemiology 161 (10): 901–15. doi:10.1093/aje/kwi121. PMID 15870154. 
  • Hildebrandt AG, Schwarz D, Krusekopf S, et al. (2007). "Recalling P446. P4501A1 (CYP1A1) opting for clinical application.". Drug Metabolism Reviews 39 (2-3): 323–41. doi:10.1080/03602530701498026. PMID 17786624.