Bifenil-2,3-diol 1,2-dioksigenaza

Izvor: Wikipedia
Bifenil-2,3-diol 1,2-dioksigenaza
2ZI8.png
Identifikatori
EC broj 1.13.11.39
CAS broj 103679-58-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Bifenil-2,3-diol 1,2-dioksigenaza (EC 1.13.11.39, 2,3-dihidroksibifenilna dioksigenaza, bifenil-2,3-diolna dioksigenaza, bphC (gen)) je enzim sa sistematskim imenom bifenil-2,3-diol:kiseonik 1,2-oksidoreduktaza (deciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

bifenil-2,3-diol + O2 \rightleftharpoons 2-hidroksi-6-okso-6-fenilheksa-2,4-dienoat

Ovaj enzim sadrži Fe2+ ili Mn2+. On učestvuje u degradaciji bifenila i PCB (poli hlorinatih bifenila)

Reference[uredi - уреди]

  1. Eltis, L.D., Hofmann, B., Hecht, H.J., Lunsdorf, H. and Timmis, K.N. (1993). "Purification and crystallization of 2,3-dihydroxybiphenyl 1,2-dioxygenase". J. Biol. Chem. 268: 2727–2732. PMID 8428946. 
  2. Uragami, Y., Senda, T., Sugimoto, K., Sato, N., Nagarajan, V., Masai, E., Fukuda, M. and Mitsu, Y. (2001). "Crystal structures of substrate free and complex forms of reactivated BphC, an extradiol type ring-cleavage dioxygenase". J. Inorg. Biochem. 83: 269–279. PMID 11293547. 
  3. Hatta, T., Mukerjee-Dhar, G., Damborsky, J., Kiyohara, H. and Kimbara, K. (2003). "Characterization of a novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase from a polychlorinated biphenyl- and naphthalene-degrading Bacillus sp. JF8". J. Biol. Chem. 278: 21483–21492. PMID 12672826. 
  4. Wesche, J., Hammer, E., Becher, D., Burchhardt, G. and Schauer, F. (2005). "The bphC gene-encoded 2,3-dihydroxybiphenyl-1,2-dioxygenase is involved in complete degradation of dibenzofuran by the biphenyl-degrading bacterium Ralstonia sp. SBUG 290". J. Appl. Microbiol. 98: 635–645. PMID 15715866. 
  5. Iwata, K., Nojiri, H., Shimizu, K., Yoshida, T., Habe, H. and Omori, T. (2003). "Expression, purification, and characterization of 2′-aminobiphenyl-2,3-diol 1,2-dioxygenase from carbazole-degrader Pseudomonas resinovorans strain CA10". Biosci. Biotechnol. Biochem. 67: 300–307. PMID 12728990. 

Literatura[uredi - уреди]

Vanjske veze[uredi - уреди]