Beta-karoten 3-hidroksilaza
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| Beta-karoten 3-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.129 | ||||||||
| CAS broj | 133425-64-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Beta-karoten 3-hidroksilaza (EC 1.14.13.129, beta-karotenska 3,3'-monooksigenaza, CrtZ) je enzim sa sistematskim imenom beta-karoten,NADH:kiseonik 3-oksidoreduktaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- beta-karoten + 2 NADH + 2 H+ + 2 O2 zeaksantin + 2 NAD+ + 2H2O
(sveukupna reakcija)
- (1a) beta-karoten + NADH + H+ + O2 beta-kriptoksantin + NAD+ + H2O
- (1b) beta-kriptoksantin + NADH + H+ + O2 zeaksantin + NAD+ + H2O
Za rado ovog enzima je neophodan feredoksin i Fe(II). On takođe deluje on druge karotenoide sa beta-krajnjom grupom.
Reference[uredi | uredi kod]
- ↑ Sun, Z., Gantt, E. and Cunningham, F.X., Jr. (1996). „Cloning and functional analysis of the β-carotene hydroxylase of Arabidopsis thaliana”. J. Biol. Chem. 271: 24349-24352. PMID 8798688.
- ↑ Fraser, P.D., Miura, Y. and Misawa, N. (1997). „In vitro characterization of astaxanthin biosynthetic enzymes”. J. Biol. Chem. 272: 6128-6135. PMID 9045623.
- ↑ Fraser, P.D., Shimada, H. and Misawa, N. (1998). „Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay”. Eur. J. Biochem. 252: 229-236. PMID 9523693.
- ↑ Bouvier, F., Keller, Y., d'Harlingue, A. and Camara, B. (1998). „Xanthophyll biosynthesis: molecular and functional characterization of carotenoid hydroxylases from pepper fruits (Capsicum annuum L.)”. Biochim. Biophys. Acta 1391: 320-328. PMID 9555077.
- ↑ Linden, H. (1999). „Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation”. Biochim. Biophys. Acta 1446: 203-212. PMID 10524195.
- ↑ Zhu, C., Yamamura, S., Nishihara, M., Koiwa, H. and Sandmann, G. (2003). „cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development”. Biochim. Biophys. Acta 1625: 305-308. PMID 12591618.
- ↑ Choi, S.K., Matsuda, S., Hoshino, T., Peng, X. and Misawa, N. (2006). „Characterization of bacterial β-carotene 3,3′-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli”. Appl. Microbiol. Biotechnol. 72: 1238-1246. PMID 16614859.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.