Benzoil-KoA reduktaza
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| Benzoil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.7.8 | ||||||||
| CAS broj | 176591-18-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Benzoil-KoA reduktaza (EC 1.3.7.8, benzoil-KoA reduktaza (dearomatizacija)) je enzim sa sistematskim imenom cikloheksa-1,5-dien-1-karbonil-KoA:feredoksin oksidoreduktaza (aromatizacija, formira ATP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- cikloheksa-1,5-dien-1-karbonil-KoA + oksidovani feredoksin + 2 ADP + 2 fosfat benzoil-KoA + redukovani feredoksin + 2 ATP + 2H2O
Ovaj enzim je gvožđe-sumporni protein. Za njegov rad je neophodan Mg2+ ili Mn2+. Neaktivan je prema aromatičnnim kiselinama koje nisu KoA esteri.
Reference[uredi | uredi kod]
- ↑ Boll, M. and Fuchs, G. (1995). „Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172”. Eur. J. Biochem. 234: 921-933. PMID 8575453.
- ↑ Kung, J.W., Baumann, S., von Bergen, M., Muller, M., Hagedoorn, P.L., Hagen, W.R. and Boll, M. (2010). „Reversible biological Birch reduction at an extremely low redox potential”. J. Am. Chem. Soc. 132: 9850-9856. PMID 20578740.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.