Atrolizin C

Izvor: Wikipedia
Atrolizin C
Identifikatori
EC broj 3.4.24.42
CAS broj 158886-17-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Atrolizin C (EC 3.4.24.42, Crotalus atrox metaloendopeptidaza c, hemoragijsk toksin c, hemoragijski toksin d) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu i Gly23-Phe veza u B lancu insulina. Na malim molekulima postoji preferencija za hidrofobne ostatke u P2' i male ostatke poput Ala, Gly u P1

Ova hemoragična endopeptidaza je prisutna u venumu zvečarke Crotalus atrox.

Reference[uredi - уреди]

  1. Bjarnason, J.B. and Tu, A.T. (1978). "Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry 17: 3395–3404. PMID 210790. 
  2. Fox, J.W., Campbell, R., Beggerly, L. and Bjarnason, J.B. (1986). "Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom". Eur. J. Biochem. 156: 65–72. PMID 3514216. 
  3. Bjarnason, J.B. and Fox, J.W. (1987). "Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom". Biochim. Biophys. Acta 911: 356–363. PMID 3101740. 
  4. Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom". Arch. Biochem. Biophys. 253: 108–121. PMID 2949699. 
  5. Shannon, J.D., Baramova, E.N., Bjarnason, J.B. and Fox, F.W. (1989). "Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin". J. Biol. Chem. 264: 11575–11583. PMID 2745407. 
  6. Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- (1990). "2, isolated from the venom of Crotalus ruber ruber". J. Biochem. (Tokyo) 108: 711–719. PMID 2081731. 

Literatura[uredi - уреди]

Vanjske veze[uredi - уреди]