Aralkilamin N-acetiltransferaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Aralkilamin N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 2.3.1.87 | ||||||||
| CAS broj | 92941-56-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aralkilamin N-acetiltransferaza (EC 2.3.1.87, serotoninska acetiltransferaza, serotoninska acetilaza, arilalkilaminska N-acetiltransferaza, serotoninska N-acetiltransferaza, AANAT, enim melatoninskog ritma) je enzim sa sistematskim imenom acetil-KoA:2-ariletilamin N-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + 2-ariletilamin KoA + N-acetil-2-ariletilamin
Ovaj enzim je specifičan za 2-ariletilamine, uključujući serotonin (5-hidroksitriptamin), triptamin, 5-metoksitriptamin i feniletilamin.
Reference[uredi | uredi kod]
- ↑ Voisin, P., Namboodiri, M.A.A. and Klein, D.C. (1984). „Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland”. J. Biol. Chem. 259: 10913-10918. PMID 6469990.
- ↑ Ferry, G., Loynel, A., Kucharczyk, N., Bertin, S., Rodriguez, M., Delagrange, P., Galizzi, J.P., Jacoby, E., Volland, J.P., Lesieur, D., Renard, P., Canet, E., Fauchere, J.L. and Boutin, J.A. (2000). „Substrate specificity and inhibition studies of human serotonin N-acetyltransferase”. J. Biol. Chem. 275: 8794-8805. PMID 10722724.
- ↑ Khalil, E.M. and Cole, P.A. (1998). „A potent inhibitor of the melatonin rhythm enzyme”. J. Am. Chem. Soc. 120: 6195-6196.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.