Aminopeptidaza I
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| Aminopeptidaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.22 | ||||||||
| CAS broj | 9031-94-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminopeptidaza I (EC 3.4.11.22, aminopeptidaza III, aminopeptidaza yscI, leucinska aminopeptidaza IV, kvaščana aminopeptidaza I) je enzim sa sistematskim imenom '.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalne aminokiseline, preferentno neutralne ili hidrofobne, sa polipeptida. Aminoacil-arilamidi su slabi supstrati
Ovaj 640 kDa težak dodekamerni enzim je najpoznatiji kao glavna vakuolarna aminopeptidaza kod kvasca.
Reference[uredi | uredi kod]
- ↑ Johnson, M.J. (1941). „Isolation and properties of a pure yeast polypeptidase”. J. Biol. Chem. 137: 575-586.
- ↑ Metz, G. and Rohm, K.-H. (1976). „Yeast aminopeptidase I. Chemical composition and catalytic properties”. Biochim. Biophys. Acta 429: 933-949. PMID 5147.
- ↑ Chang, Y-H. and Smith, J.A. (1989). „Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae”. J. Biol. Chem. 264: 6979-6983. PMID 2651436.
- ↑ Oda, M.N., Scott, S.V., Hefner-Gravink, A., Caffarelli, A.D. and Klionsky, D.J. (1996). „Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I”. J. Cell Biol. 132: 999-1010. PMID 8601598.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.