Alfa-litička endopeptidaza
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| Alfa-litička endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.12 | ||||||||
| CAS broj | 37288-76-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Alfa-litička endopeptidaza (EC 3.4.21.12, miksobakter alfa-litička proteinaza, alfa-litička proteinaza, alfa-litička proteaza, Mycobakterija sorangium alfa-litička proteinaza, Myxobacter 495 alfa-litička proteinaza, Myxobacter alfa-litička proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno odvajanje: Ala-, Val- u bakterijskim ćelijskim zidovima, elastinu i drugim proteinima
Ovaj enzim je izolovan iz miksobakterije Lysobacter enzimogena.
Reference[uredi | uredi kod]
- ↑ Olson, M.O.J., Nagabushan, N., Dzwiniel, M., Smillie, L.B. and Whitaker, D.R. (1970). „Primary structure of α-lytic protease: a bacterial homologue of the pancreatic serine proteases”. Nature 228: 438-442. PMID 5482494.
- ↑ Polgár, L. (1987). „Structure and function of serine proteases”. u: Neuberger, A. and Brocklehurst, K.. New Comprehensive Biochemistry: Hydrolytic Enzymes. 16. Amsterdam: Elsevier. str. 159-200.
- ↑ Epstein, D.M. and Wensink, P.C. (1988). „The α-lytic protease gene of Lysobacter enzymogenes. The nucleotide sequence predicts a large prepro-peptide with homology to pro-peptides of other chymotrypsin-like enzymes”. J. Biol. Chem. 263: 16586-16590. PMID 3053694.
- ↑ Bone, R., Frank, D., Kettner, C.A. and Agard, D.A. (1989). „Structural analysis of specificity: α-lytic protease complexes with analogues of reaction intermediates”. Biochemistry 28: 7600-7609. PMID 2611204.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Polgár, L. (1987). „Structure and function of serine proteases”. u: Neuberger, A. and Brocklehurst, K.. New Comprehensive Biochemistry: Hydrolytic Enzymes. 16. Amsterdam: Elsevier. str. 159-200.