Aktivator faktora V zmijskog venuma
Prijeđi na navigaciju
Prijeđi na pretragu
| Aktivator faktora V zmijskog venuma | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.95 | ||||||||
| CAS broj | 123757-15-3, 123757-16-4, 123757-17-5, 123757-18-6&title= 471269-12-2, 123757-15-3, 123757-16-4, 123757-17-5, 123757-18-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aktivator faktora V zmijskog venuma (EC 3.4.21.95, Snake venom factor V activator) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Potpuna aktivacija ljudskog faktora zgrušavanja V jednim presecanjem Trp-Tyr-Leu-Arg1545-Ser-Asn-Asn--Gly veze. Goveđi, ali ne i zečji, faktor V se preseca, i ne dolazi do reakcije na drugim proteinima sistema zgrušavanja. Esterazna aktivnost je primećena na Bz-Arg-OEt i Tos-Arg-OMe, i amidazna na Phe-pipekolil-Arg-NHPhNO2
Ovaj enzim je izolovan iz venuma Vipera russelli.
Reference[uredi | uredi kod]
- ↑ Kisiel, W. and Canfield, W. (1981). „M. Snake venom proteases that activate blood-coagulation factor V”. Methods Enzymol. 80: 275-285. PMID 7043192.
- ↑ Tokunaga, F., Nagasawa, K., Tamura, S., Miyata, T., Iwanaga, S. and Kisiel, W. (1988). „The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-Vα, -Vβ and -Vγ and their complete amino acid sequences”. J. Biol. Chem. 263: 17417-17481. PMID 3053712.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.