Adenozilkobirno kiselinska sintaza (glutamin-hidrolizujuća)
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| Adenozilkobirno kiselinska sintaza (glutamin-hidrolizujuća) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.5.10 | ||||||||
| CAS broj | 137672-90-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Adenozilkobirno kiselinska sintaza (glutamin-hidrolizujuća) (EC 6.3.5.10, CobQ, kobirinsko kiselinska sintaza, 5'-dezoksi-5'-adenozilkobirinska-kiselina-a,c-diamid:L-glutamin amido-ligaza, Ado-kobirinsko kiselinska sintaza (glutaminska hidroliza)) je enzim sa sistematskim imenom kobirinovodonična kiselina-a,c-diamid:L-glutamin amido-ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4 ATP + adenozilkobirinska kiselina a,c-diamid + 4 L-glutamin + 4H2O 4 ADP + 4 fosfat + adenozilkobirinska kiselina + 4 L-glutamat
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference[uredi | uredi kod]
- ↑ Blanche, F., Couder, M., Debussche, L., Thibaut, D., Cameron, B. and Crouzet, J. (1991). „Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans”. J. Bacteriol. 173: 6046-6051. PMID 1917839.
- ↑ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390-412. PMID 12195810.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.