3-oksoacil-(acil-nosilac-protein) reduktaza
| 3-oksoacil-(acil-nosilac-protein) reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.100 | ||||||||
| CAS broj | 37250-34-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3-oksoacil-(acil-nosilac-protein) reduktaza (EC 1.1.1.100, beta-ketoacil-(acil-nosilac protein) (ACP) reduktaza, beta-ketoacil acil nosilac protein (ACP) reduktaza, beta-ketoacilna reduktaza, beta-ketoacil tioesterska reduktaza, beta-ketoacil-ACP reduktaza, beta-ketoacil-acil nosilac-protein reduktaza, 3-ketoacil acil nosilac-protein reduktaza, NADPH-specifična 3-oksoacil-(acil nosilac-protein) reduktaza, 3-oksoacil-(ACP)reduktaza, (3R)-3-hidroksiacil-(acil-nosilac-protein):NADP+ oksidoreduktaza) je enzim sa sistematskim imenom (3R)-3-hidroksiacil-[acil-carrier protein]:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (3R)-3-hidroksiacil-[acil-nosilac protein] + NADP+ 3-oksoacil-[acil-nosilac protein] + NADPH + H+
Ovaj enzim pokazuju znatnu supstratnu preferenciju za acil-noseće-proteinske derivate u odnosu na KoA derivative.
Reference[uredi | uredi kod]
- ↑ Prescott, D.J. and Vagelos, P.R. (1972). „Acyl carrier protein”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269-311. PMID 4561013.
- ↑ Shimakata, T. and Stumpf, P.K. (1982). „Purification and characterizations of β-ketoacyl-[acyl-carrier-protein] reductase, β-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves”. Arch. Biochem. Biophys. 218: 77-91. PMID 6756317.
- ↑ Toomey, R.E. and Wakil, S.J. (1966). „Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of β-ketoacyl acyl carrier protein reductase from Escherichia coli”. Biochim. Biophys. Acta 116: 189-197. PMID 4381013.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.