2'-N-acetilparomaminska deacetilaza

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2'-N-acetilparomaminska deacetilaza
Identifikatori
EC broj 3.5.1.112
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

2'-N-acetilparomaminska deacetilaza (EC 3.5.1.112, btrD (gen), neoL (gen), kanN (gen)) je enzim sa sistematskim imenom 2'-N-acetilparomamin hidrolaza (formira acetat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2'-N-acetilparomamin + H2O \rightleftharpoons paromamin + acetat

Ovaj enzim učestvuje u biosintezi nekoliko klinički važnih aminociklitolnih antibiotika.

Reference[uredi - уреди]

  1. Truman, A.W., Huang, F., Llewellyn, N.M. and Spencer, J.B. (2007). "Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin". Angew. Chem. Int. Ed. Engl. 46: 1462–1464. PMID 17226887. 
  2. Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. (2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9: 865–869. PMID 18311744. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]