2'-Hidroksikokain

2'-Hidroksikokain
(IUPAC) ime
	metil (1R,2R,3S,5S)-3-(2-hidroksibenzoiloksi)-8-metil-8-azabiciklo[3.2.1] oktane-2-karboksilat
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	10519659
Hemijski podaci
Formula	C17H21NO5
Mol. masa	319,351
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H21NO5/c1-18-10-7-8-12(18)15(17(21)22-2)14(9-10)23-16(20)11-5-3-4-6-13(11)19/h3-6,10,12,14-15,19H,7-9H2,1-2H3/t10-,12+,14-,15+/m0/s1 ; Key: PEISRHQJLATJPJ-MMMKDXCPSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

2'-Hidroksikokain (Salicilmetilekgonin) je tropanski derivat koji je sintetički analog i mogući aktivni metabolit kokaina.^[3] Njegova potentnost in vitro je oko deset puta veća od kokaina,^[4] mada je samo tri puta potentniji od kokaina kad se ispituje na miševima.^[5]

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Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Singh S, Basmadjian GP, Avor K, Pouw B, Seale TW. A convenient synthesis of 2'- or 4'-hydroxycocaine. Synthetic Communications. 1997;27(22):4003-4012.
↑ el-Moselhy TF, Avor KS, Basmadjian GP. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie (Weinheim). 2001 Sep;334(8-9):275-8. PMID 11688137
↑ Seale TW, Avor K, Singh S, Hall N, Chan HM, Basmadjian GP. 2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding. Neuroreport. 10 November 1997;8(16):3571-5. PMID 9427328

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Singh S, Basmadjian GP, Avor K, Pouw B, Seale TW. A convenient synthesis of 2'- or 4'-hydroxycocaine. Synthetic Communications. 1997;27(22):4003-4012.

[4] -Moselhy TF, Avor KS, Basmadjian GP. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie (Weinheim). 2001 Sep;334(8-9):275-8. PMID 11688137

[5] Seale TW, Avor K, Singh S, Hall N, Chan HM, Basmadjian GP. 2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding. Neuroreport. 10 November 1997;8(16):3571-5. PMID 9427328

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2'-Hidroksikokain

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Reference[uredi | uredi kod]

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