2',3'-Ciklični-nukleotid 3'-fosfodiestaraza
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| 2',3'-Ciklični-nukleotid 3'-fosfodiestaraza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.1.4.37 | ||||||||
| CAS broj | 60098-35-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2',3'-Ciklični-nukleotid 3'-fosfodiestaraza (EC 3.1.4.37, ciklična-CMP fosfodiesteraza, 2',3'-ciklična AMP fosfodiesteraza, ciklična 2',3'-nukleotidna 3'-fosfodiesteraza, ciklična 2',3'-nukleotidna fosfodiesteraza, 2',3'-ciklična nukleozid monofosfatna fosfodiesteraza, 2',3'-ciklična nukleotidna 3'-fosfohidrolaza, CNPaza, 2',3'-ciklična nukleotidna fosfohidrolaza, 2':3'-ciklična nukleotidna 3'-fosfodiesteraza, 2':3'-CNMP-3'-aza) je enzim sa sistematskim imenom nukleozid-2',3'-ciklična-fosfat 2'-nukleotidohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nukleozid 2',3'-ciklična fosfat + H2O nukleozid 2'-fosfat
Moždani enzim deluje na 2',3'-ciklična AMP brže nego na UMP ili CMP derivate.
Reference[uredi | uredi kod]
- ↑ Drummond, G.I., Iyer, N.T. and Keith, J. (1962). „Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain”. J. Biol. Chem. 237: 3535-3539.
- ↑ Helfman, D.M. and Kuo, J.F. (1982). „A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2′:3′- and 3′:5′-nucleotides”. J. Biol. Chem. 257: 1044-1047. PMID 6274851.
- ↑ Helfman, D.M., Shoji, M. and Kuo, J.F. (1981). „Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP”. J. Biol. Chem. 256: 6327-6334. PMID 6263914.
- ↑ Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S. (1981). „Chemical, immunological and catalytic properties of 2′:3′-cyclic nucleotide 3′-phosphodiesterase purified from brain white matter”. Biochem. J. 195: 153-157. PMID 6272743.
- ↑ Nishizawa, Y., Kurihara, T. and Takahashi, Y. (1980). „Spectrophotometric assay, solubilization and purification of brain 2′:3′-cyclic nucleotide 3′-phosphodiesterase”. Biochem. J. 191: 71-82. PMID 6258586.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.