1-Fosfatidilinozitol 4-kinaza
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| 1-Fosfatidilinozitol 4-kinaza | |||||||||
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| Fosfatidilinozitolna 4-kinaza homo16mer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.1.67 | ||||||||
| CAS broj | 37205-54-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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1-Fosfatidilinozitol 4-kinaza (EC 2.7.1.67, fosfatidilinozitolna kinaza (fosforilacija), fosfatidilinozitolna 4-kinaza, fosfatidilinozitolna kinaza, tip II fosfatidilinozitolna kinaza, PI kinaza, PI 4-kinaza) je enzim sa sistematskim imenom ATP:1-fosfatidil-1D-mio-inozitol 4-fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovu reakciju katalizuju najmanje dve različite izoforme.
Reference[uredi | uredi kod]
- ↑ Colodzin, M. and Kennedy, E.P. (1965). „Biosynthesis of diphosphoinositide in brain”. J. Biol. Chem. 240: 3771-3780. PMID 4284712.
- ↑ Kai, M., White, G.L. and Hawthorne, J.N. (1966). „The phosphatidylinositol kinase of rat brain”. Biochem. J. 101: 328-337. PMID 4290722.
- ↑ Walker, D.H., Dougherty, N. and Pike, L.J. (1988). „Purification and characterization of a phosphatidylinositol kinase from A431 cells”. Biochemistry 27: 6504-6511. PMID 2851325.
- ↑ Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L. (1988). „Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate”. Nature 332: 644-646. PMID 2833705.
- ↑ Barylko, B., Gerber, S.H., Binns, D.D., Grichine, N., Khvotchev, M., Sudhof, T.C. and Albanesi, J.P. (2001). „A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans”. J. Biol. Chem. 276: 7705-7708. PMID 11244087.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.