(Heparan sulfat)-glukozamin 3-sulfotransferaza 2
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(heparan sulfat)-glukozamin 3-sulfotransferaza 2 | |||||||||
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Identifikatori | |||||||||
EC broj | 2.8.2.29 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(heparan sulfat)-glukozamin 3-sulfotransferaza 2 (EC 2.8.2.29, glukozaminilna 3-O-sulfotransferaza, heparan sulfat D-glukozaminilna 3-O-sulfotransferaza, izoforma/izozim 2 (3-OST-2, HS3ST2)) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin 3-sulfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-glukozamin 3-sulfat
Ovaj enzim sulfatiše ostatke označene asteriskom u sekvencama koje sadrže -> IdoA2S-> GlcN*-> ili -> GlcA2S-> GlcN*->.
Reference[uredi | uredi kod]
- ↑ Shworak, N.W., Liu, J., Petros, L.M., Copeland, N.G. (1999). „, Jenkins N.A. and Rosenberg, R.D. Diversity of the extensive heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST) multigene family”. J. Biol. Chem. 274: 5170-5184. PMID 9988767.
- ↑ Liu, J., Shworak, N.W., Sina, P., Schwartz, J.J., Zhang, L., Fritze, L.M.S. and Rosenberg, R.D. (1999). „Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities”. J. Biol. Chem. 274: 5185-5192. PMID 9988768.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.