Sorbinil

Sorbinil
	(4S)-6-Fluoro-2,3-dihydro-2’H,5’H-spiro[chromene-4,4’-imidazolidine]-2’,5’-dione
Drugi nazivi	(S)-6-Fluorospiro(hroman-4,4'-imidazolidin)-2',5'-dion; CP 45634
Identifikacija
CAS registarski broj	68367-52-2
PubChem	337359
ChemSpider	298991
ChEMBL	CHEMBL7681
Jmol-3D slike	Slika 1
SMILES
	Fc3ccc2OCC[C@@]1(C(=O)NC(=O)N1)c2c3
InChI
	InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1 ; Kod: LXANPKRCLVQAOG-NSHDSACASA-N InChI=InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
Svojstva
Molekulska formula	C11H9FN2O3
Molarna masa	236.2 g mol−1
Agregatno stanje	beli ili bezbojni prah
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Sorbinil je inhibitor aldozne reduktaze. Pfizer je razvijao ovaj molekul za lečenje dijabetičkih komplikacija, kao što us neuropatija i retinopatija.^[6] Klinička ispitivanja tokom 1980-tih su pokazala da ovaj materijal manifestuje idiosincratičnu toksičnost. Kod pojedinih pacijenata je uzrokovao blag osip kože, dok je reakcija jednog drugog dela pacijanata bila daleko gora. Kod njih se koža oljuštila do te mere da im je bio neophodan tretman za opekotine.^[7]

Literatura[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Sorbinil at Sigma-Aldrich
↑ MacCari, R; Del Corso, A; Giglio, M; Moschini, R; Mura, U; Ottanà, R (2011). „In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors”. Bioorganic & medicinal chemistry letters 21 (1): 200–3. DOI:10.1016/j.bmcl.2010.11.041. PMID 21129963.
↑ Lila Guterman (Sep 2011). „Covalent drugs form long-lived ties”. C&EN 89: 19-26.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Sorbinil at Sigma-Aldrich

[6] MacCari, R; Del Corso, A; Giglio, M; Moschini, R; Mura, U; Ottanà, R (2011). „In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors”. Bioorganic & medicinal chemistry letters 21 (1): 200–3. DOI:10.1016/j.bmcl.2010.11.041. PMID 21129963.

[7] Lila Guterman (Sep 2011). „Covalent drugs form long-lived ties”. C&EN 89: 19-26.

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Sorbinil

Literatura[uredi | uredi kod]

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