Hinolinat sintaza
(Preusmjereno sa stranice NadA)
Hinolinat sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.5.1.72 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hinolinat sintaza (EC 2.5.1.72, NadA, QS, hinolinatna sintetaza) je enzim sa sistematskim imenom gliceron fosfat:iminosukcinatna alkiltransferaza (ciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- gliceron fosfat + iminozukcinat piridin-2,3-dikarboksilat + 2H2O + fosfat
Ovah gvožđe-sumporni protein sadrži [4Fe-4S] klaster.
Reference[uredi | uredi kod]
- ↑ Ollagnier-de Choudens, S., Loiseau, L., Sanakis, Y., Barras, F. and Fontecave, M. (2005). „Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis”. FEBS Lett. 579: 3737-3743. PMID 15967443.
- ↑ Katoh, A., Uenohara, K., Akita, M. and Hashimoto, T. (2006). „Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid”. Plant Physiol. 141: 851-857. PMID 16698895.
- ↑ Sakuraba, H., Tsuge, H., Yoneda, K., Katunuma, N. and Ohshima, T. (2005). „Crystal structure of the NAD biosynthetic enzyme quinolinate synthase”. J. Biol. Chem. 280: 26645-26648. PMID 15937336.
- ↑ Rousset, C., Fontecave, M. and Ollagnier de Choudens, S. (2008). „The [4Fe-4S] cluster of quinolinate synthase from Escherichia coli: Investigation of cluster ligands”. FEBS Lett. 582: 2937-2944. PMID 18674537.
- ↑ Saunders, A.H. and Booker, S.J. (2008). „Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation”. Biochemistry 47: 8467-8469. PMID 18651751.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.