Lijaza S-specifična sporna fotoprodukta
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Lijaza S-specifična sporna fotoprodukta | |||||||||
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Identifikatori | |||||||||
EC broj | 4.1.99.15 | ||||||||
CAS broj | 37290-70-3 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Lijaza S-specifična sporna fotoprodukta (EC 4.1.99.15, SAM, SP lijaza, SPL, SplB, SplG) je enzim sa sistematskim imenom S-specifični sporski fotoprodukt pirimidin-lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5S)-5,6-dihidro-5-(timidin-7-il)timidin (u DNK) + S-adenozil-L-metionin timidilil-(3'->5')-timidilat (u DNK) + 5'-dezoksiadenozin + L-metionin
Ovaj enzim sadrži gožđe-sumporni centar.
Reference[uredi | uredi kod]
- ↑ Chandor, A., Berteau, O., Douki, T., Gasparutto, D., Sanakis, Y., Ollagnier-de-Choudens, S., Atta, M. and Fontecave, M. (2006). „Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis”. J. Biol. Chem. 281: 26922-26931. PMID 16829676.
- ↑ Pieck, J.C., Hennecke, U., Pierik, A.J., Friedel, M.G. and Carell, T. (2006). „Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates”. J. Biol. Chem. 281: 36317-36326. PMID 16968710.
- ↑ Mehl, R.A. and Begley, T.P. (1999). „Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct”. Org Lett 1: 1065-1066. PMID 10825958.
- ↑ Friedel, M.G., Berteau, O., Pieck, J.C., Atta, M., Ollagnier-de-Choudens, S., Fontecave, M. and Carell, T. (2006). „The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion”. Chem. Commun. (Camb.): 445-447. PMID 16493831.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.