GNA13

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Guanin nukleotid-vezujući protein (G protein), alfa 13
PDB prikaz baziran na 1zcb.
Dostupne strukture
1zcb
Identifikatori
Simboli	GNA13; G13; MGC46138
Vanjski ID	OMIM: 604406 MGI: 95768 HomoloGene: 55976 GeneCards: GNA13 Gene
Ontologija gena Molekularna funkcija • vezivanje nukleotida • aktivnost GTPaze • aktivnost receptora signalnih proteina • vezivanje proteina • GTP vezivanje Celularna komponenta • membrana Biološki proces • obrazovaje krvnih sudova • in utero embrionski razvoj • ćelijska motilnost • prenos signala • signalni put G-protein spregnutog receptora • kaskada protein kinaza • Ro protein signalna transdukcija • regulacija ćelijskog oblika • ćelijska diferencijacija • aktivacija trombocita • regulacija ćelijske migracije
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	10672	14674
Ensembl	ENSG00000120063	ENSMUSG00000020611
UniProt	Q14344	Q3UE40
RefSeq (mRNA)	NM_006572	NM_010303
RefSeq (protein)	NP_006563	NP_034433
Lokacija (UCSC)	Chr 17: 60.44 - 60.48 Mb	Chr 11: 109.18 - 109.21 Mb
PubMed pretraga	[1]	[2]

GNA13, Guanin nukleotid-vezujući protein alfa 13 je protein koji je kod ljudi kodiran GNA13 genom.

Interactions

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, AKAP3, RIC8A, Radixin i ARHGEF12.

Literatura

• Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Liya Yin, Xu SM, and Coughlin SR (2005). „Essential role for Galpha 13 in endothelial cells during embryonic development.”. Proc. Natl. Acad. Sci. U.S.A. 102 (22): 8281–8286. DOI:10.1073/pnas.0503326102. PMC 1149452. PMID 15919816. 
• Downes GB, Gautam N (2000). „The G protein subunit gene families.”. Genomics 62 (3): 544–52. DOI:10.1006/geno.1999.5992. PMID 10644457. 
• Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). „G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.”. Proc. Natl. Acad. Sci. U.S.A. 91 (2): 504–8. DOI:10.1073/pnas.91.2.504. PMC 42977. PMID 8290554. 
• Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. DOI:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586. 
• Offermanns S, Hu YH, Simon MI (1996). „Galpha12 and galpha13 are phosphorylated during platelet activation.”. J. Biol. Chem. 271 (42): 26044–8. DOI:10.1074/jbc.271.42.26044. PMID 8824244. 
• Offermanns S, Mancino V, Revel JP, Simon MI (1997). „Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency.”. Science 275 (5299): 533–6. DOI:10.1126/science.275.5299.533. PMID 8999798. 
• Macrez-Leprêtre N, Kalkbrenner F, Morel JL, et al. (1997). „G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes.”. J. Biol. Chem. 272 (15): 10095–102. DOI:10.1074/jbc.272.15.10095. PMID 9092554. 
• Hart MJ, Jiang X, Kozasa T, et al. (1998). „Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.”. Science 280 (5372): 2112–4. DOI:10.1126/science.280.5372.2112. PMID 9641916. 
• Fukuhara S, Murga C, Zohar M, et al. (1999). „A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.”. J. Biol. Chem. 274 (9): 5868–79. DOI:10.1074/jbc.274.9.5868. PMID 10026210. 
• Becker KP, Garnovskaya M, Gettys T, Halushka PV (1999). „Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.”. Biochim. Biophys. Acta 1450 (3): 288–96. DOI:10.1016/S0167-4889(99)00068-3. PMID 10395940. 
• Windh RT, Lee MJ, Hla T, et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351–8. DOI:10.1074/jbc.274.39.27351. PMID 10488065. 
• Brydon L, Roka F, Petit L, et al. (2000). „Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.”. Mol. Endocrinol. 13 (12): 2025–38. DOI:10.1210/me.13.12.2025. PMID 10598579. 
• Bhattacharyya R, Wedegaertner PB (2000). „Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.”. J. Biol. Chem. 275 (20): 14992–9. DOI:10.1074/jbc.M000415200. PMID 10747909. 
• Vaiskunaite R, Adarichev V, Furthmayr H, et al. (2000). „Conformational activation of radixin by G13 protein alpha subunit.”. J. Biol. Chem. 275 (34): 26206–12. DOI:10.1074/jbc.M001863200. PMID 10816569. 
• Shi CS, Sinnarajah S, Cho H, et al. (2000). „G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.”. J. Biol. Chem. 275 (32): 24470–6. DOI:10.1074/jbc.M908449199. PMID 10821841. 
• Ponimaskin E, Behn H, Adarichev V, et al. (2000). „Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.”. FEBS Lett. 478 (1-2): 173–7. DOI:10.1016/S0014-5793(00)01845-7. PMID 10922491. 
• Jin S, Exton JH (2000). „Activation of RhoA by association of Galpha(13) with Dbl.”. Biochem. Biophys. Res. Commun. 277 (3): 718–21. DOI:10.1006/bbrc.2000.3744. PMID 11062019. 
• Fukuhara S, Chikumi H, Gutkind JS (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.”. FEBS Lett. 485 (2-3): 183–8. DOI:10.1016/S0014-5793(00)02224-9. PMID 11094164. 
• Meigs TE, Fields TA, McKee DD, Casey PJ (2001). „Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.”. Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. DOI:10.1073/pnas.021350998. PMC 14619. PMID 11136230. 

Vidi još

• G protein