GNA12
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GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.[1][2][3]
Interakcije[uredi | uredi kod]
Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,[4] ARHGEF12,[5][6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1[7] i TEC.[6]
Reference[uredi | uredi kod]
- ↑ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Stuart A. Aaronson (Feb 1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800.
- ↑ Kumar RN, Shore SK, Dhanasekaran N (Feb 2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene 25 (6): 899–906. DOI:10.1038/sj.onc.1209132. PMID 16247467.
- ↑ „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”.
- ↑ Yamaguchi, Yoshiaki; Katoh Hironori, Mori Kazutoshi, Negishi Manabu (August 2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. (England) 12 (15): 1353–8. DOI:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367.
- ↑ Fukuhara, S; Chikumi H, Gutkind J S (November 2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. (NETHERLANDS) 485 (2-3): 183–8. DOI:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164.
- ↑ 6,0 6,1 Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (January 2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. DOI:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866.
- ↑ Vaiskunaite, R; Kozasa T, Voyno-Yasenetskaya T A (December 2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. (United States) 276 (49): 46088–93. DOI:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136.
