COPG2

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Koatomerni proteinski kompleks, podjedinica gama 2
Identifikatori
Simboli COPG2; 2-COP; DKFZp761N09121; FLJ11781
Vanjski ID OMIM604355 HomoloGene56292 GeneCards: COPG2 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 26958 54160
Ensembl n/a ENSMUSG00000025607
UniProt n/a n/a
RefSeq (mRNA) NM_012133 NM_017478.2
RefSeq (protein) NP_036265 NP_059506.1
Lokacija (UCSC) n/a Chr 6:
30.7 - 30.85 Mb
PubMed pretraga [1] [2]

Koatomerna podjedinica gama-2 je protein koji je kod ljudi kodiran COPG2 genom.[1][2][3]

Interakcije[uredi - уреди]

Za COPG2 je pokazano da formira interakcije sa dopaminskim receptorom D1[4] i COPB1.[5][6]

Izvori[uredi - уреди]

  1. Blagitko N, Schulz U, Schinzel AA, Ropers HH, Kalscheuer VM (Jan 2000). "gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome". Hum Mol Genet 8 (13): 2387–96. DOI:10.1093/hmg/8.13.2387. PMID 10556286. 
  2. Yamasaki K, Hayashida S, Miura K, Masuzaki H, Ishimaru T, Niikawa N, Kishino T (Nov 2000). "The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting". Genomics 68 (3): 330–5. DOI:10.1006/geno.2000.6265. PMID 10995575. 
  3. "Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26958. 
  4. Bermak, Jason C; Li Ming, Bullock Clayton, Weingarten Paul, Zhou Qun-Yong (Feb. 2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085. 
  5. Takatsu, H; Futatsumori M, Yoshino K, Yoshida Y, Shin H W, Nakayama K (Jun. 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. DOI:10.1006/bbrc.2001.5081. ISSN 0006-291X. PMID 11409905. 
  6. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2000). "Identification and characterization of novel isoforms of COP I subunits.". J Biochem 128 (5): 793–801. PMID 11056392. 

Literatura[uredi - уреди]

  • Pelham HR, Rothman JE (2000). "The debate about transport in the Golgi--two sides of the same coin?". Cell 102 (6): 713–9. DOI:10.1016/S0092-8674(00)00060-X. PMID 11030615. 
  • Waters MG, Serafini T, Rothman JE (1991). "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles.". Nature 349 (6306): 248–51. DOI:10.1038/349248a0. PMID 1898986. 
  • Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor.". J. Biol. Chem. 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. PMID 8940050. 
  • Harter C, Wieland FT (1998). "A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11649–54. DOI:10.1073/pnas.95.20.11649. PMID 9751720. 
  • Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23.". J. Biol. Chem. 274 (20): 14198–203. DOI:10.1074/jbc.274.20.14198. PMID 10318838. 
  • Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.". EMBO J. 19 (15): 3905–17. DOI:10.1093/emboj/19.15.3905. PMID 10921873. 
  • Futatsumori M, Kasai K, Takatsu H, et al. (2001). "Identification and characterization of novel isoforms of COP I subunits.". J. Biochem. 128 (5): 793–801. PMID 11056392. 
  • Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. DOI:10.1006/bbrc.2001.5081. PMID 11409905. 
  • Paulsson KM, Kleijmeer MJ, Griffith J, et al. (2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.". J. Biol. Chem. 277 (21): 18266–71. DOI:10.1074/jbc.M201388200. PMID 11884415. 
  • Bermak JC, Li M, Bullock C, et al. (2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.". Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. PMID 11893085. 
  • Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.". Mol. Psychiatry 7 (3): 289–301. DOI:10.1038/sj.mp.4001004. PMID 11920156. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMID 12690205. 
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMID 17353931.