COPG

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Koatomerni proteinski kompleks, podjedinica gama

PDB prikaz baziran na 1pzd.
Dostupne strukture
1pzd, 1r4x
Identifikatori
Simboli COPG; COPG1; FLJ21068
Vanjski ID MGI1858696 HomoloGene56745 GeneCards: COPG Gene
Pregled RNK izražavanja
PBB GE COPG 217749 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 22820 54161
Ensembl ENSG00000181789 ENSMUSG00000030058
UniProt Q9Y678 n/a
RefSeq (mRNA) NM_016128 NM_017477
RefSeq (protein) NP_057212 NP_059505
Lokacija (UCSC) Chr 3:
128.97 - 129 Mb
Chr 6:
87.84 - 87.86 Mb
PubMed pretraga [1] [2]

Koatomerna podjedinica gama je protein koji je kod ljudi kodiran COPG genom.[1][2]

Interakcije[uredi - уреди]

Za COPG je pokazano da formira interakcije sa dopaminskim receptorom D1,[3] COPZ1[4][5] i COPB1.[1][6]

Reference[uredi - уреди]

  1. 1.0 1.1 Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (February 2001). "Identification and characterization of novel isoforms of COP I subunits". J Biochem 128 (5): 793–801. PMID 11056392. 
  2. "Entrez Gene: COPG coatomer protein complex, subunit gamma". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22820. 
  3. Bermak, Jason C; Li Ming, Bullock Clayton, Weingarten Paul, Zhou Qun-Yong (February 2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085. 
  4. Faulstich, D; Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland F T, Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. DOI:10.1083/jcb.135.1.53. ISSN 0021-9525. PMID 8858162. 
  5. Lowe, M; Kreis T E (November 1996). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. ISSN 0021-9258. PMID 8940050. 

Literatura[uredi - уреди]

  • Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor.". J. Biol. Chem. 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. PMID 8940050. 
  • Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. DOI:10.1073/pnas.95.5.2140. PMID 9482852. 
  • Fischer KD, Helms JB, Zhao L, Wieland FT (2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.". Methods 20 (4): 455–64. DOI:10.1006/meth.2000.0958. PMID 10720466. 
  • Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.". EMBO J. 19 (15): 3905–17. DOI:10.1093/emboj/19.15.3905. PMID 10921873. 
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. DOI:10.1073/pnas.160270997. PMID 10931946. 
  • Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.". Mol. Biol. Cell 11 (9): 3155–68. PMID 10982407. 
  • Hahn Y, Lee YJ, Yun JH, et al. (2000). "Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution.". FEBS Lett. 482 (1–2): 31–6. DOI:10.1016/S0014-5793(00)02033-0. PMID 11018518. 
  • Paulsson KM, Kleijmeer MJ, Griffith J, et al. (2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. 277 (21): 18266–71. DOI:10.1074/jbc.M201388200. PMID 11884415. 
  • Bermak JC, Li M, Bullock C, et al. (2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. PMID 11893085. 
  • Kanzaki M, Watson RT, Hou JC, et al. (2003). "Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes". Mol. Biol. Cell 13 (7): 2334–46. DOI:10.1091/mbc.01-10-0490. PMID 12134073. 
  • Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell 13 (10): 3493–507. DOI:10.1091/mbc.E02-01-0004. PMID 12388752. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Rohde HM, Cheong FY, Konrad G, et al. (2004). "The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex". J. Biol. Chem. 278 (52): 52689–99. DOI:10.1074/jbc.M307983200. PMID 14527956. 
  • Watson PJ, Frigerio G, Collins BM, et al. (2004). "Gamma-COP appendage domain - structure and function". Traffic 5 (2): 79–88. DOI:10.1111/j.1600-0854.2004.00158.x. PMID 14690497. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMID 17353931.