Holinesteraza
(Preusmjereno sa stranice Antiholinesteraza)
| Holinesteraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.1.1.8 | ||||||||
| CAS broj | 2593805 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Holinesteraza (EC 3.1.1.8, pseudoholinesteraza, butirilholin esteraza, nespecifična holinesteraza, holin esteraza II, benzoilholinesteraza, holin esteraza, butirilholinesteraza, propionilholinesteraza, antiholinesteraza, BtChoEase) je enzim sa sistematskim imenom acilholin acilhidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acilholin + H2O holin + karboksilat
Ovaj enzim deluje mnoštvo holinskih estara.
Reference[uredi | uredi kod]
- ↑ Augustinsson, K.-B. (1948). „Cholinesterases. A study in comparative enzymology”. Acta Physiol. Scand. 15, Suppl. 2: -.
- ↑ Augustinsson, K.-B. and Olsson, B. (1959). „Esterases in the milk and blood plasma of swine. 1. Substrate specificity and electrophoresis studies”. Biochem. J. 71: 477-484. PMID 13638253.
- ↑ Koelle, G.B. (1953). „Cholinesterases of the tissues and sera of rabbits”. Biochem. J. 53: 217-226. PMID 13032058.
- ↑ Nachmansohn, D. and Wilson, I.B. (1951). „The enzymic hydrolysis and synthesis of acetylcholine”. Adv. Enzymol. Relat. Subj. Biochem. 12: 259-339. PMID 14885021.
- ↑ Sawyer, C.H. (1945). „Hydrolysis of choline esters by liver”. Science 101: 385-386.
- ↑ Strelitz, F. (1944). „Studies on cholinesterase. 4. Purification of pseudo-cholinesterase from horse serum”. Biochem. J. 38: 86-88. PMID 16747753.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.