U46619
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| U46619 | |||
|---|---|---|---|
| |||
| IUPAC ime |
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| Identifikacija | |||
| CAS registarski broj | 56985-40-1 | ||
| PubChem[1][2] | 5311493 | ||
| ChEMBL[3] | CHEMBL357834 | ||
| IUPHAR ligand | 1888 | ||
| Jmol-3D slike | Slika 1 | ||
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| Svojstva | |||
| Molekulska formula | C21H34O4 | ||
| Molarna masa | 350,49 g/mol | ||
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
U46619 je stabilni sintetički analog prostaglandina PGH2 koji je prvi put pripremnljen 1975.[4] U46619 je vazokonstriktor koji oponaša hidroosmotičko dejstvo vazopresina.[5] On takođe oponaša dejstvo tromboksana putem aktivacije fosfolipaze C.[6][7]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Bundy, G. L. (1975). „Synthesis of prostaglandin endoperoxide analogs”. Tetrahedron Letters 24 (24): 1957–1960. DOI:10.1016/S0040-4039(00)72333-1.
- ↑ Burch, Ronald M.; Halushka, Perry V. (1983). „Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport”. Journal of Pharmacology and Experimental Therapeutics 224 (1): 108–17. PMID 6294273.
- ↑ Rittenhouse, Susan E. (1984). „Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP”. Biochemical Journal 222 (1): 103–110. PMC 1144149. PMID 6433894.
- ↑ Michael P. Walsh, et all (August 2005). „Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697”. Biochem. J. 389 (Pt 3): 763–74. DOI:10.1042/BJ20050237. PMC 1180727. PMID 15823093. Arhivirano iz originala na datum 2011-07-13. Pristupljeno 2014-04-11.
