Trimerlizin I
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| Trimerlizin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.52 | ||||||||
| CAS broj | 151125-16-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trimerlizin I (EC 3.4.24.52, Trimeresurus metaloendopeptidaza I, hemoragična proteinaza HR1A, hemoragična metaloproteinaza HR1A, metaloproteinaza HR1A) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje dve veze, His10-Leu i Ala14-Leu, u lancu insulina B
Ova hemoragična endopeptidaza je prisutna u venumu zmije Trimeresurus flavoviridis.
Reference[uredi | uredi kod]
- ↑ Omori-Satoh, T. and Sadahiro, S. (1979). „Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts”. Biochim. Biophys. Acta 580: 392-404. PMID 518906.
- ↑ Yamakawa, Y. and Omori-Satoh, T. (1988). „The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)”. Toxicon 26: 227-231. PMID 3284004.
- ↑ Takeya, H., Oda, K., Miyata, T., Omori-Satoh, T. and Iwanaga, S. (1990). „The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis”. J. Biol. Chem. 265: 16068-16073. PMID 2398046.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.