TRNK (pseudouridin54-N1)-metiltransferaza
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TRNK (pseudouridin54-N1)-metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.257 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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TRNK (pseudouridin54-N1)-metiltransferaza (EC 2.1.1.257, TrmY, m1Psi metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (pseudouridin54-N1)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + pseudouridin54 u tRNK S-adenozil-L-homocistein + N1-metilpseudouridin54 u tRNK
Ovaj arhejski enzim je specifično metiliše pseudouridin u poziciji 54.
- ↑ Chen, H.Y. and Yuan, Y.A. (2010). „Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase”. J. Mol. Cell. Biol. 2: 366-374. PMID 21098051.
- ↑ Wurm, J.P., Griese, M., Bahr, U., Held, M., Heckel, A., Karas, M., Soppa, J. and Wohnert, J. (2012). „Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs”. RNA 18: 412-420. PMID 22274954.
- ↑ Chatterjee, K., Blaby, I.K., Thiaville, P.C., Majumder, M., Grosjean, H., Yuan, Y.A., Gupta, R. and de Crecy-Lagard, V. (2012). „The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA”. RNA 18: 421-433. PMID 22274953.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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