3(ili 17)a-hidroksisteroid dehidrogenaza
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3(ili 17)a-hidroksisteroid dehidrogenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.1.1.209 | ||||||||
CAS broj | 83294-77-3 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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3(ili 17)a-hidroksisteroid dehidrogenaza (EC 1.1.1.209, 3(17)alfa-hidroksisteroid dehidrogenaza) je enzim sa sistematskim imenom 3(or 17)alfa-hidroksisteroid:NAD(P)+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- androsteron + NAD(P)+ 5alfa-androstan-3,17-dion + NAD(P)H + H+
Deluje na 3alfa-hidroksi grupe androgena iz 5alfa-androstan serija; kao i u manjoj meri na 17alfa-hidroksi grupe androgenih I estrogenih supstrata (cf. EC 1.1.1.51 3(ili 17)beta-hidroksisteroid dehidrogenaza).
- ↑ Lau, P.C.K., Layne, D.S. and Williamson, D.G. (1982). „A 3(17)α-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme”. J. Biol. Chem. 257: 9444-9449. PMID 6955302.
- ↑ Lau, P.C.K., Layne, D.S. and Williamson, D.G. (1982). „Comparison of the multiple forms of the soluble 3(17)α-hydroxysteroid dehydrogenases of female rabbit kidney and liver”. J. Biol. Chem. 257: 9450-9456. PMID 6955303.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
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