Pertuzumab

Izvor: Wikipedia
Pertuzumab
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 380610-27-5
ATC kod L01XC13
DrugBank DB06366
ChEMBL[1] CHEMBL2007641 YesY
Hemijski podaci
Formula  ?
Farmakokinetički podaci
Poluvreme eliminacije 18 dana
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status
Način primene Intravenozno

Pertuzumab (2C4, prodajno ime Perjeta) monoklonalno antitelo je za tretman HER2-positivnog raka dojke. On se koristi u kombinaciji sa trastuzumabom i docetakselom.[2] Ovaj lek je privi u klasi agenasa zvanih „HER dimerizacini inhibitori“. Vezivanjem za HER2, on inhibira dimerizaciju HER2 sa drugim HER receptorima, i smatra se da to dovodi do usporavanja rasta tumora.[3] FDA je odobrila pertuzumab za lečenje HER2-pozitivnog metastatičkog raka dojke u junu 2012.[4][5][6][7]

Reference[uredi - уреди]

  1. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  2. Pertuzumab
  3. de Bono, Johann S.; Bellmunt, J; Attard, G; Droz, JP; Miller, K; Flechon, A; Sternberg, C; Parker, C et al. (20. 1. 2007.). "Open-Label Phase II Study Evaluating the Efficacy and Safety of Two Doses of Pertuzumab in Castrate Chemotherapy-Naive Patients With Hormone-Refractory Prostate Cancer". Journal of Clinical Oncology 25 (3): 257–262. doi:10.1200/JCO.2006.07.0888. PMID 17235043. 
  4. "FDA Approves Perjeta (Pertuzumab) for People With HER2-Positive Metastatic Breast Cancer" (Press release). Genentech. Retrieved 9. 6. 2012.. 
  5. Protein sequence Link:www.freepatentsonline.com/20110117097.pdf
  6. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  7. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901–6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]

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