XRCC1

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XRCC1

PDB prikaz baziran na 1cdz.
Dostupne strukture
1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 3LQC
Identifikatori
SimboliXRCC1; RCC
Vanjski IDOMIM194360 MGI99137 HomoloGene31368 GeneCards: XRCC1 Gene
Pregled RNK izražavanja
PBB GE XRCC1 203655 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez751522594
EnsemblENSG00000073050ENSMUSG00000051768
UniProtP18887Q60596
RefSeq (mRNA)NM_006297.2NM_009532.4
RefSeq (protein)NP_006288.2NP_033558.3
Lokacija (UCSC)Chr 19:
44.05 - 44.08 Mb
Chr 7:
25.33 - 25.36 Mb
PubMed pretraga[1][2]

XRCC1 je protein popravke DNK. On formira kompleks sa DNK ligazom III.

Ovaj protein učestvuje u popravci jednolančankih prekida DNK formiranih izlaganjem jonizujućoj radijaciji i alkilujućim agensima. Ovaj protein formira interakcije sa DNK ligazom III, polimerazom beta i poli ADP-riboznom polimerazom da bi učestvovao u putu popravke isecanjem baza. Moguće je da ima ulogu u DNK manipulacijama tokom mejoze i rekombinacije u ćelijama zametka. Retki mikrosatelitni polimorfizam ovog genu je vezan za pojavu pojedinih tipova kancera.[1]

Interakcije[uredi - уреди | uredi izvor]

XRCC1 formira interakcije sa PARP2,[2] DNK polimerazom beta,[3][4][5][6] Aprataksinom,[7][8] Oksoguaninskom glikosilaza,[9] PCNA,[4] APEX1,[10] PNKP[11][12] i PARP1.[8][13]

Reference[uredi - уреди | uredi izvor]

  1. "Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7515. 
  2. Schreiber, Valérie; Amé Jean-Christophe, Dollé Pascal, Schultz Inès, Rinaldi Bruno, Fraulob Valérie, Ménissier-de Murcia Josiane, de Murcia Gilbert (June 2002). "Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1". J. Biol. Chem. (United States) 277 (25): 23028–36. ISSN 0021-9258. PMID 11948190. doi:10.1074/jbc.M202390200. 
  3. Wang, Liming; Bhattacharyya Nandan, Chelsea Diane M, Escobar Pedro F, Banerjee Sipra (November 2004). "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype". Cancer Res. (United States) 64 (21): 7673–7. ISSN 0008-5472. PMID 15520167. doi:10.1158/0008-5472.CAN-04-2801. 
  4. 4,0 4,1 Fan, Jinshui; Otterlei Marit, Wong Heng-Kuan, Tomkinson Alan E, Wilson David M (2004). "XRCC1 co-localizes and physically interacts with PCNA". Nucleic Acids Res. (England) 32 (7): 2193–201. PMC 407833. PMID 15107487. doi:10.1093/nar/gkh556. 
  5. Kubota, Y; Nash R A, Klungland A, Schär P, Barnes D E, Lindahl T (December 1996). "Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein". EMBO J. (ENGLAND) 15 (23): 6662–70. ISSN 0261-4189. PMC 452490. PMID 8978692. 
  6. Bhattacharyya, N; Banerjee S (July 2001). "A novel role of XRCC1 in the functions of a DNA polymerase beta variant". Biochemistry (United States) 40 (30): 9005–13. ISSN 0006-2960. PMID 11467963. doi:10.1021/bi0028789. 
  7. Date, Hidetoshi; Igarashi Shuichi, Sano Yasuteru, Takahashi Toshiaki, Takahashi Tetsuya, Takano Hiroki, Tsuji Shoji, Nishizawa Masatoyo, Onodera Osamu (December 2004). "The FHA domain of aprataxin interacts with the C-terminal region of XRCC1". Biochem. Biophys. Res. Commun. (United States) 325 (4): 1279–85. ISSN 0006-291X. PMID 15555565. doi:10.1016/j.bbrc.2004.10.162. 
  8. 8,0 8,1 Gueven, Nuri; Becherel Olivier J, Kijas Amanda W, Chen Philip, Howe Orla, Rudolph Jeanette H, Gatti Richard, Date Hidetoshi, Onodera Osamu, Taucher-Scholz Gisela, Lavin Martin F (May 2004). "Aprataxin, a novel protein that protects against genotoxic stress". Hum. Mol. Genet. (England) 13 (10): 1081–93. ISSN 0964-6906. PMID 15044383. doi:10.1093/hmg/ddh122. 
  9. Marsin, Stéphanie; Vidal Antonio E, Sossou Marguerite, Ménissier-de Murcia Josiane, Le Page Florence, Boiteux Serge, de Murcia Gilbert, Radicella J Pablo (November 2003). "Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1". J. Biol. Chem. (United States) 278 (45): 44068–74. ISSN 0021-9258. PMID 12933815. doi:10.1074/jbc.M306160200. 
  10. Vidal, A E; Boiteux S, Hickson I D, Radicella J P (November 2001). "XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions". EMBO J. (England) 20 (22): 6530–9. ISSN 0261-4189. PMC 125722. PMID 11707423. doi:10.1093/emboj/20.22.6530. 
  11. Whitehouse, C J; Taylor R M, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko D D, Weinfeld M, Caldecott K W (January 2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell (United States) 104 (1): 107–17. ISSN 0092-8674. PMID 11163244. doi:10.1016/S0092-8674(01)00195-7. 
  12. Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134. 
  13. Masson, M; Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G (June 1998). "XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3563–71. ISSN 0270-7306. PMC 108937. PMID 9584196. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]