WAY-100635

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WAY-100635
(IUPAC) ime
N-[2-[4-(2-metoksifenil)-1-piperazinil]etil]- N-(2-piridil)cikloheksankarboksamid
Klinički podaci
Identifikatori
CAS broj 146714-97-8
ATC kod nije dodeljen
PubChem[1][2] 5684
ChEMBL[3] CHEMBL31354 YesY
Hemijski podaci
Formula C25H34N4O2 
Mol. masa 422,56 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

WAY-100,635 je piperazinski lek koji je u širokoj upotrebi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni 5-HT1A antagonist, ali su naknadna istraživanja pokazala da on isto tako deluje kao potentan pun agonist na D4 receptoru.[4][5][6] On se ponekad naziva nemim antagonistom 5-HT1A receptora.[7] WAY-100,635 i WAY-100,135 su hemijski slični.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs (1996). "WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135". The Journal of Pharmacology and Experimental Therapeutics 278 (2): 752–762. PMID 8768728. 
  5. Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols (October 2006). "WAY-100635 is a potent dopamine D4 receptor agonist". Psychopharmacology 188 (2): 244–251. PMID 16915381. doi:10.1007/s00213-006-0490-4. 
  6. Marona-Lewicka D, Nichols DE (2009). "WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation". Behav Pharmacol 20 (1): 114–8. PMID 19179855. doi:10.1097/FBP.0b013e3283242f1a. 
  7. A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish (1996). "Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist". Behavioural Brain Research 73 (1-2): 337–333. PMID 8788530. doi:10.1016/0166-4328(96)00118-0. 

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