Vinorin sintaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Vinorin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.160 | ||||||||
| CAS broj | 88844-97-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Vinorin sintaza (EC 2.3.1.160) je enzim sa sistematskim imenom acil-KoA:16-epivelozimin O-acetiltransferaza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + 16-epivelozimin KoA + vinorin
Ova reakcija se odvija u dva stupnja.
Reference[uredi | uredi kod]
- ↑ Pfitzner, A., Polz, L. and Stöckligt, J. (1986). „Properties of vinorine synthase the Rauwolfia enzyme involved in the formation of the ajmaline skeleton”. Z. Naturforsch. C: Biosci. 41: 103-114.
- ↑ Bayer, A., Ma, X. and Stöckigt, J. (2004). „Acetyltransfer in natural product biosynthesis—functional cloning and molecular analysis of vinorine synthase”. Bioorg. Med. Chem. 12: 2787-2795. PMID 15110860.
- ↑ Ma, X., Koepke, J., Bayer, A., Linhard, V., Fritzsch, G., Zhang, B., Michel, H. and Stöckigt, J. (2004). „Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily”. Biochim. Biophys. Acta 1701: 129-132. PMID 15450182.
- ↑ Ma, X., Koepke, J., Panjikar, S., Fritzsch, G. and Stöckigt, J. (2005). „Crystal structure of vinorine synthase, the first representative of the BAHD superfamily”. J. Biol. Chem. 280: 13576-13583. PMID 15665331.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.